Resources .

What is Design of Experiments? In this series of blogs, we'll explore the foundations of DOE, who it's for, and the benefits of using it.

What is Design of Experiments (DOE)?

Michael "Sid" Sadowski, PhD

14 min

No idea which type of design is right for your Design of Experiments (DOE)? Michael (aka Sid) Sadowski, PhD, sets the record straight for beginners.

3 main types of Design of Experiments (DOE) designs

Michael "Sid" Sadowski, PhD

16 min

Heard of Design of Experiments (DOE), but wondering what stages and steps are involved in the process? James (JAJA) Arpino, PhD, gives you a simple ...

The DOE process: A step-by-step guide

James Arpino, PhD

9 min

sid-and-jaja-doe-training-course-authors-synthace-1

Free 8-day email course

DOE training delivered to your inbox

Synthace’s biologists turned DOE evangelists Sid and JAJA teach you the DOE fundamentals in under 6 minutes a day. Without the statistical overload.

Expand your DOE knowledge

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There are lots of books on DOE out there, all aimed at a variety of audiences. We rifle through our bookshelf and pick 7 of our favorites worth reading.

7 Design of Experiments books we love in 2025

Michael "Sid" Sadowski, PhD

13 min

A Biologist's Guide to Design of Experiments | eBook

Keen to learn more? Download our ebook to demystify Design of Experiments methodology, and get step by step instructions for how to run DOE.

DOE Office Hours - Applying DOE | Webinar

Watch Synthace’s biologists and DOE evangelists Sid and Nathan answer your questions on applying DOE to your biological experimentation.

Podcast

The next experiment

Understanding complex living systems is impossibly tricky. But does it have to be?

Join Markus and Phil, a biologist and a statistician, as they explore the shape of the next experiment.

Synthace in Action

Charles River Laboratories: Robust, hassle-free assay development and transfer

How CRL used Synthace to rapidly optimize a biochemical assay directly in a 1536-well plate, ...

University of Oxford: Optimizing a new enzymatic assay in just 3 weeks

How the University of Oxford used Synthace DOE to rapidly develop a new biochemical assay, and ...

GSK: Rapid development of better, cheaper cell-based assays

How GSK improved the quality of their calcium FLIPR assay using Synthace DOE, whilst reducing ...

Design of Experiments (DOE) with Oxford Biomedica

Using Synthace, Oxford Biomedica has been able to design, plan and execute a reduced time ...

Space-Fill Design of Experiments (DOE) with Synthace and the Dragonfly® Discovery

We combine the speed and accuracy of SPT Labtech’s dragonfly® discovery dispenser with the ...

Uncommon: Accelerating Media Optimization using DOE

Learn how Uncommon managed to successfully optimize cultivated meat media using DOE on ...

Senior Research Scientist Luci interviews Roxana Redis, Associate Science Director at Charles River Laboratories, who works in drug discovery.

Innocent Meat: Fast iPSC media optimization

How Innocent Meat used Synthace to speed up iPSC media optimization, developing a media ...

Learn from drug discovery leaders

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A Synthesis interview

Meet Roxana Redis, Associate Science Director at Charles River Laboratories

Lucia Dunajová, PhD

8 min

A Synthesis interview

Meet Thomas Pesnot, Drug Discovery Services Director at Concept Life Sciences

Emily interviews Thomas Pesnot, Drug Discovery Services Director at Concept Life Sciences, a UK based CRO offering discovery services to clients worldwide.

Emily Tipper, PhD

7 min

A Synthesis interview

Meet Thierry Dorval, Head of Data Science and Management at Servier

Senior Research Scientist Luci interviews Thierry Dorval, Head of Data Sciences and Management at Servier, located in Europe’s Silicon Valley.

Lucia Dunajová, PhD

7 min

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University of Oxford: Optimizing a new enzymatic assay in just 3 weeks

How the University of Oxford used Synthace DOE to rapidly develop a new biochemical assay, and run experiments previously thought impossible.

Innocent Meat: Fast iPSC media optimization

How Innocent Meat used Synthace to speed up iPSC media optimization, developing a media formulation that increased cell count by 250% in just a few weeks.

GSK: Rapid development of better, cheaper cell-based assays

How GSK improved the quality of their calcium FLIPR assay using Synthace DOE, whilst reducing both costs and reagent usage.

Uncommon: Accelerating Media Optimization using DOE

Learn how Uncommon managed to successfully optimize cultivated meat media using DOE on Synthace in a fraction of the usual time and cost.

DOE Office Hours. The Basics

Learn about DOE in this mini webinar series run by our in-house experts.

DOE Office Hours. Applying DOE

Learn about applying DOE in this mini webinar series run by our in-house experts.

DOE Office Hours. About Synthace DOE

Learn about how Synthace makes it easy to apply DOE to biological experimentation.

DOE Masterclass 1
Why It Will Transform Your Biological Research

In Part 1 of the DOE Masterclass for Biologists, Dr Markus Gershater will talk through the tools and tips to understand biological complexity through ...

DOE Masterclass Part 2
Real World Applications to DOE

In DOE Masterclass Part 2, Dr James Arpino will help you apply DOE to your biological research, navigate experimental complexity and deepen your ...

DOE Masterclass Part 3
How to Get Started with DOE

In DOE Masterclass Part 3, Dr Steven Brown walks us through where to start in a DOE. How you can set experiment goals, constants, and variables to get the ...

DOE Masterclass:
Analysis - What Really Matters

Many scientists find the idea of modeling their results scary. But modeling is a great tool for organizing your thinking.

DOE Masterclass:
Anyone can run DOEs

Learn how anyone can easily run complex end-to-end experiments with Synthace DOE.

DOE Masterclass:
What If Your Response Is a Curve

Design of Experiments (DOE) gives biologists huge power to understand complex systems.

DOE Masterclass:
Quality by Design for discovery in life science R&D

DOE should be a cornerstone of your Quality by Design (QbD) strategy, especially when it comes to ICH or other regulatory compliance. Learn why in this ...

DOE Masterclass:
DOE for Media Optimization

Alex Rimmer, stem cell scientist at Uncommon and Dr. Markus Gershater, CSO at Synthace discuss how DOE works for media optimization.

DOE Masterclass:
Secrets of Transformative DOE Adoption

Adopting Design of Experiments (DOE) is commonly an uphill battle.

DOE Masterclass:
the best tools for powerful DOEs

Tools that you can use to execute DOEs to get the maximum insight and context from your biological systems.

Capturing Intent and Context
in Your Lab Experiments

Examine the importance of capturing and interpreting experimental intent, scientific context, and data integrity in a successful campaign.

Syngenta: Flexible and Scalable Automation with Synthace

Syngenta is a world leading agricultural company that develops novel solutions to support farmers worldwide.

DOE Masterclass: DOE for Purification Process Optimization

Optimize your purification process to get maximum value in every experiment using DOE.

DOE Masterclass:
Optimizing Genetic Code

In this DOE Masterclass, Dr. Claes Gustafsson from Atum and Dr. Markus Gershater from Synthace will present.

Lab Automation Masterclass

Streaming live the first Wednesday of every month, modernize your lab and accelerate you lab automation adoption with advice from our in-house experts.

eBook

A Biologists Guide to Design of Experiments

Design of Experiments (DOE) is the future. It is the key to unlocking the answers hidden in complex bioligical systems and broadens the possibilities of ...

DOE For Discovery with SPTLabtech

Design of Experiments is great for exploring the unknown. In this webinar, Dr Anne Hammerstein from SPTLabtech and Dr James Arpino from Synthace will walk ...

Bioprocess Development with Synthace

Gathering data for bioprocess experiment runs is a challenge. Our team will walk through how your bioprocess development teams can centralize your ...

eBook

5 Steps to R&D Digitalization

A quick read on how to digitise your R&D to unblock your R&D with digital capabilities achieve self-sustaining adoption and flexible adaptation, prepare ...

Report

Quant-iT™ PicoGreen™ DNA Assays

We performed an automated PicoGreen™ assay using our cloud-based software platform Synthace to enable optimization of assays. Synthace achieved higher ...

Space-Fill Design of Experiments (DOE) with Synthace and the Dragonfly® Discovery

We combine the speed and accuracy of SPT Labtech’s dragonfly® discovery dispenser with the flexible experiment design capabilities of Synthace to unlock ...

CSL: Transforming Automated Micro-Purification Experiments

CSL’s Purification Team realized significant time savings in the automation of end-to-end micro-scale purification experiments on the Tecan Evo ...

Downstream Process Optimization

Walk through the stages of a downstream process optimization campaign using scale-down, high-throughput process development (HTPD) tools and share how ...

Charles River Laboratories: Robust, hassle-free assay development and transfer

How CRL used Synthace to rapidly optimize a biochemical assay directly in a 1536-well plate, and seamlessly transfer it across sites, automation and ...

Report

Rapid Automation and Analysis of a Competitive ELISA Kit with Synthace

In this study, we demonstrate the rapid and flexible automation of a kit-based competitive ELISA protocol, from design through execution to data analysis, ...

Design of Experiments (DOE) with Oxford Biomedica

Using Synthace, Oxford Biomedica has been able to design, plan and execute a reduced time frame two iteration DOE optimization and robustness study of ...

Report

Enhancing RoboColumn® Workflows with Synthace and Te-Chrom™

A detailed report on how Synthace and Tecan's Freedom EVOware Te-chrom comparatively deliver instructions on liquid handling robots for purification of ...