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Downstream Process Optimization with Synthace

This on-demand webinar explores Synthace Miniaturized Purification solution. Walk through the stages of a downstream process optimization campaign using scale-down, high-throughput process development (HTPD) tools and see how Synthace can help along the way.

In this video we:

Discuss the benefits of HTPD tools with a focus on filter plates and OPUS® RoboColumns®, for downstream process development on Tecan® devices;
Highlight the importance of data and metadata tracking at different steps of your process;
Show you how Synthace can help you design, execute and gain insights from scale-down purification experiments, while leveraging Design of Experiments (DOE), with some real-life examples from our lab.

WATCH NOW:

DOE Downstream Process Optimization - SQ 1-1

Background

In downstream processing, there is no perfect ‘one size fits all’ process for the range of new products that come through the biomanufacturing pipeline. Therefore, downstream process optimization is essential but can still be highly time, effort, and resource intensive.

Scale-down, high-throughput process development (HTPD) tools have been instrumental in making process optimization more efficient as they make use of automation, need fewer materials, and allow the investigation of a high number of different purification conditions in a single experiment.

In combination with a Design of Experiments (DOE) methodology, scientists can gain a comprehensive understanding of their process prior to scaling up. However, planning, programming automation, and wrangling the data for such experiments can be challenging, time-consuming, and require specialist training.

The speakers

Lucia Dunajova, PhD

Senior Scientist, Synthace

Lucia Dunajova, PhD

Senior Scientist, Synthace

Lucia works at the intersection of science and engineering to push the Synthace platform forward.

Her recent work has focused on using Synthace and high-throughput process development tools to exemplify protein purification applications.

Prior to joining Synthace, Lucia was a Senior Scientist at OXGENE where she engineered cell lines for lentiviral production.

Lucia was awarded her PhD by the University of Nottingham.

Victoria Gonzalez, PhD

Product Manager, Synthace

Victoria Gonzalez, PhD

Product Manager, Synthace

Victoria works in our product team, collaborating closely with engineers to continuously improve and expand the functionality of the Synthace platform.

Her focus is on the lab execution part of the experiment journey, identifying and developing features that will enable scientists to achieve great results faster and more reliably, and ultimately learn more from their experiments.

Previously, Victoria worked in our Customer Success team delivering value to Synthace customers by deploying the platform for purification applications.

Victoria’s background is in cell biology and neuroscience, and she was awarded a PhD by King’s College London.