Case Study

Innocent Meat:
Fast iPSC media optimization

How Innocent Meat used Synthace to speed up iPSC media optimization, developing a media formulation that increased cell count by 250% in just a few weeks.

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At a glance

2 iterations looking at 10 factors
2.5x increase in cell proliferation after two experiments
1 week between planning and analysis

CHALLENGES

How to make cells grow fast and with less cost?

Without an accessible Design of Experiments strategy, Innocent Meatʼs team would have ended up testing each variable one by one. With ambitious plans to better understand their experimental space by investigating 6+ variables, this would have involved running hundreds of experiments - an impossible, time-consuming feat.

With Synthaceʼs team of experts and automated DOE software, Innocent Meat found a way to scale their experimentation and explore more experimental ground than ever before. By mapping out how their variables interacted with one another, they set themselves up for gaining more robust insights - in a fraction of the time.

SOLUTION

Automated DOEs with Synthace

The team at Innocent Meat used Synthace to run a DOE strategy composed of two experimental iterations - an initial screening looking at 6 key media components, followed by an optimization design which included all 10 media factors.

Innocent Meat used the Synthace software to plan the experiments and generate the automation instructions for their Formulatrix Mantis dispenser.

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Results

2.5x increase in cell proliferation

Media Optimization: The team was able to to increase cell proliferation by 50% in one experiment, and achieve 2.5x higher cell counts after two

Time and cost effective: Using Synthace and automation, they were able to go from planning to conclusive results in one week.

Paving future success: Innocent Meat established a "cut & paste" process for future media optimization campaigns

"We want cells to grow fast and with less cost. Synthace is capable of achieving both."

Anand Ramani
Technical Program Manager at Innocent Meat