Bioprocessing Informatics with Synthace

In an IUK-funded collaboration with Oxford Biomedica, the Cell and Gene Therapy Catapult and WattBe, Synthace was applied to overcome automation and data challenges to aid viral vector manufacture using advanced Process Analytical Technologies (PAT).
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Key findings
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  • Timeframe from data generation to high value bioprocess insight was reduced from weeks to minutes
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  • Synthace enabled near real-time quantification of functional viral titre, cell density and viability, and process metabolites using Raman spectroscopy, and metabolic activity using refractive index
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  • PAT in conjunction with Synthace facilitates the rapid optimization and refinement of process parameters
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In collaboration with
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