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    Multivariate Experiments > Media Optimization

    Faster and better
    media optimization.

    Optimizing media for applications like cell differentiation is a difficult balance between finding the best composition for a robust, effective process and minimizing the use of costly reagents. Synthace Discovery’s powerful high-dimensional experiments deliver the insight needed to make the best trade-offs.

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    DOE Media Optimization
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    Synthace Discovery method for a media optimization protocol
    Easy Automation

    You describe your protocol, Synthace automates it

    Synthace Discovery translates DOE and HDE designs into the accurate automation instructions needed for media optimization, even when they span multiple devices. 

    There's no need to manually convert concentrations into volumes, and then struggle with bespoke device instructions. You can create a design, and then you’re able to fully automate your experiment, across different devices, with Synthace Discovery.

     
    Simulation of a media optimization DOE, showing all the different components of a mixture in a well.
    Liquid Tracking

    Keep track of every single liquid in a well

    Complex media can have tens of components, which all need to be meticulously tracked.

    Synthace Discovery does this for you automatically. It records and lets you inspect every liquid and its concentration at any point in the experiment, creating a digital record. Even during the most complex experiment, you’ll know exactly what’s in each well and where it came from.
    Data structuring in Synthace discovery
    Data structuring

    Automatically align your data to your design

    While fully randomised designs and plates are statistical best practice, they create a challenge when it comes to assigning the correct responses to the right wells. 

    Synthace Discovery does this for you, automatically. Because Synthace knows exactly what liquid is where, it can easily assign a response to the correct design run. There's no need to handle multiple csv files, or copy and paste data. Just a few clicks and you're done.
    DOE for Media Optimisation
    Flexible analysis

    Find the best trade-off

    Optimizing growth conditions often aims at balancing different goals - the expression of the right phenotypic markers, the cell's health status and overall amounts, the cost of the media itself.

    Synthace discovery lets you model and optimize all of these together, so you can find the sweet spot.

    “In just a few months Synthace DOE saved me from performing 20,000 manual calculations—it’s all done for me.”

    Alex Rimmer | Stem Cell Scientist III, Uncommon