Define your assemblies to automate the design
Synthace’s device-agnostic software automatically converts assembly design into instructions for any device you are using
The advancement of DNA assembly is changing many fields of biotechnology, from vaccines to biomaterials. Highly efficient methods require automation that can keep up with the higher throughput. As construct assemblies utilize more parts, the number of possible outcomes increases and the throughput increases, necessitating automation. Programming devices for these processes can be a challenge, especially for complex assemblies requiring multiple parts.
Robust, reproducible designs
Synthace simplifies performing complex assemblies by automatically programming liquid handling steps, liquid transfer calculations, and providing full sample traceability.
Synthace automatically calculates all liquid handling steps, making changing protocols and assemblies easy
Synthace provides in silico experimental preview giving full sample traceability
Synthace’s Assembly Design Report gives estimated probabilities of assemblies, improving fidelity and efficacy
Elements are a key concept in Synthace. They translate human-readable actions into machine instructions. You can define how the experiment will be performed through the element input parameters.
Elements form the visual user interface to Synthace’s planning engine. Synthace interprets your requirements and translates these into complex robot instructions. Input volumes are also calculated and the labware needed is determined.
You can create workflows in Synthace by connecting elements together to specify the flow of physical materials and information.
A simple workflow example is connecting an element where liquids and their properties are defined (e.g. liquid names, concentrations, pH, and so on) with an element that aliquots these liquids onto a plate as desired.
Synthace’s execution preview shows a layout of your device, and clearly shows where labware needs to be placed and the amount and location of your reagents.
The preview also shows every liquid handling action in order of execution with a useful step-by-step time estimate. This minimizes the chances of errors, and gives you an immediate estimate of walk-away time. Hovering over individual transfers will indicate the selected liquid handling policies.
Synthace’s Assembly Report automatically keeps track of the parts and lengths of your assembly as well as calculates your assembly's fidelity without the need for additional software. This increases the assembly's robustness and reproducibility. Keeping all experimental files and reports on one page reduces manual data matching which can be slow and error-prone.
Synthace for DNA Assembly is available on:
The Synthace planning engine parses the high-level inputs specified in your workflow, including the experimental design, selected labware and deck layout. The planning engine converts these instructions into low-level instructions such as the liquid handling steps and the exact labware positions on your predefined deck layout.
Yes, custom deck layouts can be chosen in Synthace. The user can define multiple deck configurations for the same liquid handler mode.
SynthaceHub automatically sends log and configuration files to the cloud for storage in your organization’s private data repository in Synthace from the liquid handler’s native software.
Although calendar integrations are not yet available in Synthace, the estimated run times as calculated by Synthace’s planning engine provide an accurate timing for you to ensure that you have booked enough time on your desired devices to execute your experiments.
Synthace will work out the changes necessary to implement your workflow. You simply need to upload your deck configuration and re-simulate — Synthace will use your new worktable layout to determine the necessary instructions.
Synthace comes with its own library of different liquid handling policies for all types of liquids. You can select different liquid handling policies for each of the liquid handling steps. Different samples can have different policies, and these policies can be linked to your liquid classes on certain liquid handling devices.
Experimental results can be searched and accessed by everyone in your group/organization who has an account in Synthace. If you would like to discuss access control and data security in more detail, please drop us an email or use the “Request a demo” button above.
We were founded by a team of biologists in 2011 as a bio-process service provider, optimizing the existing bio-processes of our clients using a multi-factorial experimental approach. We used automated robotic equipment to run our high-dimensional, complex experiments.
Synthace has helped us improve our business and think outside the box, and its platform has allowed us to do many things we previously couldn’t”André Raposo Group Lead - Computer-Aided Biology (CAB) group at Oxford Biomedica