Design of Experiments (DOE) with Oxford Biomedica

The Synthace platform is easier to use than all the other liquid handling automation software packages I have experienced. Oxford Biomedica User

Multifactorial optimization of lentiviral vector transfection / transduction system

Using Synthace, Oxford Biomedica has been able to design, plan and execute a reduced time frame two iteration DOE optimization and robustness study of their transfection and transduction process.

3-10X

Increase in product yield after use of automated DOE

5.5X

Reduction in process variability after one DOE iteration

32%

Reduction in tips used in liquid handling after optimization

Time saving and design complexity gains provided by Synthace. Synthace provides up to a 98% time saving on design and planning for DOEs when compared to other automated liquid handling platform software (left) whilst providing the ability to execute complex designs beyond the capability of tractable manual execution (see customer testimonial table in the full case study). With Synthace, programming automated liquid handling platforms for high complexity experimentation reduces the burden of alternative solutions without compromising on complexity (right).

Using Synthace, Oxford Biomedica has been able to design, plan and execute a reduced time frame two iteration DOE optimization and robustness study of their transfection and transduction process.

Synthace provided up to an 83% time saving from combined design, planning, and physical execution and a 32% resource saving allowing Oxford Biomedica scientists to focus on the analysis of their results and experimental planning, driving their research and development forwards, rather than focusing on repetitive and error-prone manual execution.

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